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ACROBiosystems Mouse IL-10 Protein, His Tag

Marke:  ACROBiosystems IL0-M4248-20UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15827017

  • 184.24 CHF / 20 Mikrogramm


Verfügbar ab
28-05-2021
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Beschreibung

Beschreibung

Interleukin-10 (IL-10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. Mature human IL-10 shares 72% - 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract. Patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body.

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 19.6 kDa. The protein migrates as 21 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_034678
HEK293
Mouse
19.6 kDa
20 µg
Ser 19 - Ser 178
CSIF,IL-10,IL10A,TGIF,B-TCGF,GVHDS,MGC126450,MGC126451,RP11-262N9.1,Interleukin-10
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Cytokines and Growth Factors
Powder
>92% as determined by SDS-PAGE
Mouse IL-10, His Tag (IL0-M4248) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Ser 178 (Accession # NP_034678).
-20°C
IL-10
His Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation