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Gibco™ Mouse FGF-23 Recombinant Protein, PeproTech®
Recombinant Protein
Marke: Gibco™ 450-55-100UG
825.84 CHF gültig bis 2025-03-28
Benutzen Sie den Promotions-Code "24107" um Ihren Promotions-Preis zu erhalten.
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Beschreibung
450-55-1MG will be provided as 2 x 500 μg (450-55-500UG). Recombinant Murine FGF-23 is a 25.5 kDa globular protein containing 228 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets, an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia, a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
Spezifikation
| Q9EPC2 | |
| protein with no preservative | |
| 25.5 kDa | |
| 100 μg | |
| RUO | |
| ADHR; FGF; Fgf23; FGF-23; FGFN; Fibroblast growth factor; Fibroblast growth factor 23; Fibroblast growth factor 23 C-terminal peptide; Fibroblast growth factor 23 N-terminal peptide; HPDR2; HYPF; Phosphatonin; PHPTC; tumor-derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor; UNQ3027/PRO9828 | |
| FGF23 | |
| Unconjugated | |
| MYPDTSPLLG SNWGSLTHLY TATARTSYHL QIHRDGHVDG TPHQTIYSAL MITSEDAGSV VITGAMTRRF LCMDLHGNIF GSLHFSPENC KFRQWTLENG YDVYLSQKHH YLVSLGRAKR IFQPGTNPPP FSQFLARRNE VPLLHFYTVR PRRHTRSAED PPERDPLNVL KPRPRATPVP VSCSRELPSA EEGGPAASDP LGVLRRGRGD ARGGAGGADR CRPFPRFV | |
| E. coli | |
| ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Functional Assay | |
| 64654 | |
| Mouse FGF-23 | |
| E. coli | |
| <1 EU/ μg | |
| FGF23 | |
| Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.5 ug/ml, in the presence of murine Klotho and heparin. | |
| Recombinant | |
| -20°C | |
| Lyophilized |
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