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MMS19 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Thermo Scientific PA563283
Additional Details : Gewicht : 0.02000kg
Beschreibung
Immunogen sequence: IVPLFLDGNV SFLPENSFPS RFQPFQDGSS GQRRLIALLM AFVCSLPRNV EIPQLNQLMR ELLELSCCHS CPFSSTAAAK CFAGLLNKHP A Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 84%.
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.Spezifikation
MMS19 | |
Polyclonal | |
Unconjugated | |
MMS19 | |
2410001K24Rik; 2610042O15Rik; AI316855; C79368; C86341; hMMS19; homolog of yeast MMS19; incisor protein; MET18; MET18 homolog; Mms19; MMS19 (MET18 S. cerevisiae); MMS19 cytosolic iron-sulfur assembly component; MMS19 homolog, cytosolic iron-sulfur assembly component; MMS19 nucleotide excision repair homolog; MMS19 nucleotide excision repair homolog (S. cerevisiae); MMS19 nucleotide excision repair protein homolog; MMS19 nucleotide excision repair-like; Mms19l; MMS19-like (MET18 homolog, S. cerevisiae); MMS19-like protein | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
64210 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry, Western Blot | |
0.2 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q96T76 | |
MMS19 | |
Recombinant protein corresponding to Human MMS19 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only