MMP13 Monoclonal Antibody (LIPCO IID1), Invitrogen™

Beschreibung

MA5-14247 targets MMP-13 (Collagenase-3) (Rat) in IF, IP, and WB applications and shows reactivity with mouse and Rat samples. The MA5-14247 immunogen is rat MMP-13 from BC-1 cells.

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.