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MERTK Monoclonal Antibody (DS5MMER), Super Bright™ 600, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

175.00 CHF - 409.00 CHF

Spezifikation

Antigen MERTK
Klon DS5MMER
Konzentration 0.2 mg/mL
Anwendungen Flow Cytometry
Klassifikation Monoclonal
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15825613
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Affymetrix eBioscience
63-5751-82
100 μg
409.00 CHF
100 Mikrogramm
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Verfügbar ab: 16-04-2024
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15815613
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Invitrogen
63-5751-80
25 μg Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11.
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Beschreibung

Beschreibung

Description: This DS5MMER monoclonal antibody recognizes mouse MerTK, a 170-210 kDa member of the TAM family of tyrosine kinase receptors that also includes Axl and Tyro3. MerTK is expressed on tissue macrophages and is involved in the removal of apoptotic cells. This process relies on two soluble ligands of MerTK, Protein S and Gas6 that bind to phosphatidylserine found on the outer leaflet of the plasma membrane of cells undergoing apoptosis. Upon binding these ligands, MerTK undergoes autophosphorylation at multiple tyrosine residues that activate the PI3K and Akt pathways. This results in the phagocytosis of apoptotic cells and also results in the direct inhibition of TLR-induced production of pro-inflammatory cytokines. In addition, MerTK may function as a putative entry receptor for filoviruses. Deficiency of MerTK causes general autoimmunity, inflammation and accumulation of apoptotic bodies. MerTK is constitutively released from the cell surface by metalloproteinases and thus is present in the serum and culture medium. This process can be enhanced by stimulation with LPS. MerTK can be used to help discriminate macrophages from dendritic cells. MerTK is often expressed on maligt cells and may be implicated in immune evasion. The DS5MMER antibody will work on paraformaldehyde-fixed cells. Applications Reported: This DS5MMER antibody has been reported for use in flow cytometric analysis.

MERTK Monoclonal antibody specifically detects MERTK in Mouse samples. It is validated for Flow Cytometry.
Spezifikation

Spezifikation

MERTK
0.2 mg/mL
Monoclonal
Liquid
RUO
Q60805
Mertk
Primary
4° C, store in dark, DO NOT FREEZE!
Mertk
DS5MMER
Flow Cytometry
Super Bright 600
Rat
Mouse
17289
IgG2a κ
Affinity chromatography
Antibody
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications