Learn More
MCK10 Monoclonal Antibody (2G4E12), Invitrogen™
Mouse Monoclonal Antibody
Marke: Invitrogen MA515429
Additional Details : Gewicht : 0.01000kg
Beschreibung
MA5-15429 targets DDR1 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15429 immunogen is purified recombinant fragment of DDR1 (aa602-681) expressed in E. Coli.<br>.
DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration and other cellular processes. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.Spezifikation
MCK10 | |
Monoclonal | |
Conc. Not Determined | |
ascites with 0.03% sodium azide | |
Q08345 | |
DDR1 | |
Purified recombinant fragment of DDR1 (aa602-681) expressed in E. Coli. | |
RUO | |
780 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
ELISA, Western Blot | |
2G4E12 | |
Unconjugated | |
DDR1 | |
6030432F18; AI323681; Cak; CD167; CD167 antigen-like family member A; CD167a; Cell adhesion kinase; DAAP-278B20.1; DDR; DDR1; DDR1d; discoidin domain receptor family, member 1; discoidin domain receptor tyrosine kinase 1; discoidin receptor tyrosine kinase; Drd1; Eddr1; Epithelial discoidin domain receptor 1; epithelial discoidin domain-containing receptor 1; HGK2; mammary carcinoma kinase 10; MCK10; MCK-10; Mpk6; NEP; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase receptor type 4; neurotrophic tyrosine kinase, receptor, type 4; NTRK4; protein-tyrosine kinase 3; Protein-tyrosine kinase 3A; Protein-tyrosine kinase MPK-6; protein-tyrosine kinase PTK-3; protein-tyrosine kinase RTK-6; PTK3; PTK3A; PTK3A protein tyrosine kinase 3A; PTK3D; RTK6; TRK E; TRKE; Tyrosine kinase DDR; tyrosine-protein kinase CAK | |
Mouse | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |