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Ly-6A/E Rat anti-Mouse, PE, Clone: D7, BD

Rat Monoclonal Antibody

176.00 CHF - 665.00 CHF

Spezifikation

Antigen Ly-6A/E
Klon D7
Konzentration 0.2mg/mL
Anwendungen Flow Cytometry
Klassifikation Monoclonal
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15821609
Unterlagen ansehen Aktionsdetails
BD Biosciences
562059
25 μg
176.00 CHF
1 Stück
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Verfügbar ab: 22-04-2024
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15886998
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BD Biosciences
553108
0.2 mg
665.00 CHF
1 Stück
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Verfügbar ab: 15-04-2024
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Beschreibung

Beschreibung

The D7 antibody reacts with Ly-6A.2 and Ly-6E.1, which are allelic members of the Ly-6 multigene family. Sca-1 (Ly6A/E), a phosphatidylinositol-anchored protein of about 18 kDa, is expressed on the multipotent hematopoietic stem cells (HSC) in the bone marrow of mice with both Ly-6 haplotypes. In mice expressing the Ly-6.2 haplotype (e.g., AKR, C57BL, C57BR, C57L, C58, DBA/2, PL, SJL, SWR, 129), Ly-6A/E is also expressed on distinct subpopulations of bone marrow and peripheral B lymphocytes and thymic and peripheral T lymphocytes. Strains with the Ly-6.1 haplotype (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes, whereas activation of lymphocytes from mice of both Ly-6 haplotypes leads to strong expression of the Sca-1 antigen. Studies with the D7 antibody have demonstrated that Ly-6A/E may be involved in the regulation of B and T lymphocyte responses, and it appears to be required for T-cell receptor-mediated T-cell activation. Purified E13-161.7 mAb (anti-Ly-6A/E, Cat. No. 553333) can block binding of FITC-conjugated D7 antibody (Cat. No. 557405) to mouse splenocytes, but purified mAb D7 is unable to block binding of FITC-conjugated E13-161.7 antibody (Cat. No. 553335). Anti-Ly-6A/E (Sca-1) mAb may be used in combination with the Mouse Lineage Panel (Cat. No. 559971) to identify HSC.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Spezifikation

Spezifikation

Ly-6A/E
0.2mg/mL
Monoclonal
Rat
Mouse
IL-2-dependent mouse T-cell line CTL-L
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
D7
Flow Cytometry
PE
RUO
Aqueous buffered solution containing ≤0.09% sodium azide.
IgG2a κ
Affinity Purified
Ly-6A/E; Lymphocyte antigen 6A-2/6E-1; Ly-6A.2/Ly-6E.1; Sca-1; TAP
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Dokumentation

Dokumentation

Product Certifications

For Research Use Only.