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Lovastatin, 97%

Code produit 15499537
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5 g
25 g
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25g
5g
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Code produit Quantité Conditionnement
15499537 25 g 25g
15489537 5 g 5g
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Code produit 15499537 Fournisseur Thermo Scientific Alfa Aesar Code fournisseur H52792.14
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Verfügbar ab: 21-12-2026
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Description

CAS: 75330-75-5 | C24H36O5 | 404.55 g/mol

Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

Solubility
Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), methanol, chloroform, acetone, acetonitrile, DMF, and water (0.4 µg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.
TRUSTED_SUSTAINABILITY

Identifiants chimiques

CAS 75330-75-5
Formule moléculaire C24H36O5
Poids moléculaire (g/mol) 404.55
Numéro MDL MFCD00072164
Clé InChI PCZOHLXUXFIOCF-BXMDZJJMSA-N
Synonyme lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin
CID PubChem 53232
ChEBI CHEBI:40303
Nom IUPAC (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
SMILES CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

Spécification

Nom chimique ou matériau Lovastatin
Point de fusion 175°C
Quantité 25 g
Informations sur la solubilité Soluble in DMSO (10mg/ml),ethanol (10mg/ml),methanol,chloroform,acetone,acetonitrile,DMF,and water (0.4 μg/ml).
Poids de la formule 404.56
Pourcentage de pureté 97%

RUO – Research Use Only

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