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  5. Tocris Bioscience™ Lomitapide mesylate

Tocris Bioscience™ Lomitapide mesylate
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Artikelnummer. 18786426
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50 mg
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10 Milligramm
50 Milligramm
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18786426 50 mg 50 Milligramm
18718556 10 mg 10 Milligramm
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Artikelnummer. 18786426 Lieferant Tocris Bioscience™ Lieferanten-Nr. 7492/50

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759.00 CHF gültig bis 2026-03-31
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Description

Potent microsomal triglyceride transfer protein (MTP) inhibitor

Lomitapide mesylate is a potent inhibitor of microsomal triglyceride transfer protein (IC50 = 8 nM). Lomitapide inhibits or normalizes lipoprotein production in rodents and in a rabbit model of hypercholesterolemia. Lomitapide is antimalarial; it inhibits hemozoin formation and growth of CQ-sensitive (PfNF54) and multidrug-resistant (PfK1) strains of P. falciparum (IC50 values are 0.56 μM and 0.69 μM respectively). Orally bioavailable.
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Specifications

Chemischer Name oder Material N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4 '-(trifluoromethyl)[1,1 '-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9 H-fluorene-9-carboxamide methanesulfonate
CAS 2059395-52-5
Menge 50 mg
Ziel Lipid Metabolism Inhibitors
Summenformel C39H37F6N3O2.CH3SO3H
Reinheit 0.98
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