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LIG4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marke: Proteintech 12695-1-AP-20UL
Additional Details : Gewicht : 0.00010kg
Beschreibung
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.Spezifikation
LIG4 | |
Polyclonal | |
Unconjugated | |
LIG4 | |
DNA ligase 4, DNA ligase IV, LIG4, ligase IV, DNA, ATP dependent | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
290907, 319583, 3981 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.21 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
P49917, Q8BTF7 | |
Lig4 | |
LIG4 Fusion Protein Ag3385 | |
20 μL | |
Primary | |
Human, Rat, Mouse | |
Antibody | |
IgG |