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MUC-1 Ab-5 Hamster Monoclonal Antibody, Epredia™
Epredia™ MUC-1 Ab-5, Hamster Monoclonal Antibody provides accurate, reproducible results.
Marke: Epredia HM-1630-P1
Artikelnummer. 12638606
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610.00 CHF
388.01 CHF / 500 Mikroliter
Sparen 221.99 CHF
36% Rabatt
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Beschreibung
Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost. Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kDa) and a smaller subunit (14-28kDa) noncovalently associated with each other. Transgenic Muc1 has been shown to associate with all four erbB receptors and localize with erbB1 (EGFR) in lactating glands1. Muc1 can act as a ligand for ICAM-1 on HUVEC cells; it can bind beta-catenin, GSK3beta and it associates with Grb2-SOS upon phosphorylation.Host Species: Hamster
Clone: MH1 (CT2)
Isotype: IgG
Species Reactivity: Human and Mouse. Others not tested.
Epitope: aa 239-255
Immunogen: A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) from the cytoplasmic tail of MUC-1
Molecular Weight: 14-28kDa
Positive Control: MCF-7 cells; Breast CA
Cellular Localization: Cytoplasmic and membrane
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Immunofluorescence
- Immunoprecipitation
- Flow Cytometry
Note:
USA: RUO; Int'l: RUO
Spezifikation
| MUC-1 Ab-5 | |
| Monoclonal | |
| 200µg/mL | |
| Hamster | |
| 500 μL | |
| Cancer and Tumor Biology | |
| Human, Mouse | |
| IgG |
| Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| MH1; same as CT2 | |
| Unconjugated | |
| A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1 | |
| RUO | |
| Primary | |
| Concentrated |
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