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JMJD1C Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA566829
Additional Details : Gewicht : 0.01000kg
Beschreibung
Immunogen sequence: IIPGSVLTDLL DAMHTLREKY GIKSHCHCTN KQNLQVGNFP TMNGVSQVLQ NVLNHSNKIS LCMPESQQQN TPPKS Highest antigen sequence identity to the following orthologs - mouse 86%, rat 82%.
The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.Spezifikation
JMJD1C | |
Polyclonal | |
Unconjugated | |
JMJD1C | |
5430433L24Rik; D630035I23Rik; DKFZp761F0118; FLJ14374; Jhdm2c; JMJD1C; Jmjdic; jumonji domain containing 1C; jumonji domain-containing protein 1C; Kiaa1380; Pr2; Probable JmjC domain-containing histone demethylation protein 2C; RP11-10C13.2; thyroid hormone receptor interactor 8; thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP8; TRIP-8 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
221037 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q15652 | |
JMJD1C | |
Recombinant Human JMJD1C | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
For Research Use Only