missing translation for 'onlineSavingsMsg'
Learn More
Learn More
JIP3 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA538828
Additional Details : Gewicht : 0.00900kg
Beschreibung
c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members, JNK2 and JNK3, have been identified. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.Spezifikation
JIP3 | |
Polyclonal | |
Unconjugated | |
MAPK8IP3 | |
C-jun-amino-terminal kinase-interacting protein 3, JNK-interacting protein 3, JIP-3, JNK MAP kinase scaffold protein 3, Mitogen-activated protein kinase 8-interacting protein 3, JIP3, KIAA1066 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
23162, 30957 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Western Blot | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q9UPT6, Q9ESN9 | |
MAPK8IP3 | |
A synthetic peptide derived from the internal region of human JIP3 | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |