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Invitrogen™ Integrin beta 7 Chimeric Recombinant Rabbit Monoclonal Antibody (FIB504)
Rabbit Recombinant Monoclonal Antibody
Marke: Invitrogen™ MA548013
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Beschreibung
Specificity: FIB504 recognizes an epitope on intergin beta-7 subunit that overlaps completely with the epitope defined by Fib27 and Fib30, and also partially with the epitope defined by FIB21 and FIB22.
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.
Spezifikation
| Integrin beta 7 Chimeric | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 0.02% ProClin 300 | |
| P26010, P26011 | |
| ITGB7 | |
| FIB504 was prepared by immunizing rats with TK1 cells. | |
| 200 μg | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG κ |
| Flow Cytometry, Inhibition Assays, Immunocytochemistry | |
| FIB504 | |
| Unconjugated | |
| ITGB7 | |
| Gut homing receptor beta subunit; integrin beta 7; integrin beta 7 subunit; integrin beta-7; Integrin beta-P; integrin subunit beta 7; integrin, beta 7; ITGB7; Ly69; M290 IEL antigen | |
| Rabbit | |
| Protein A | |
| RUO | |
| 16421, 3695 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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