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Tocris Bioscience™ Imipramine hydrochloride
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Artikelnummer. 18727176
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Menge:
50 mg
Packungsgröße:
50 Milligramm
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18727176 50 mg 50 Milligramm
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Artikelnummer. 18727176 Lieferant Tocris Bioscience™ Lieferanten-Nr. 7841/50

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Beschreibung

Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment

Imipramine hydrochloride is a potent tricyclic antidepressant; inhibits 5-HT and noradrenalin transporters (Ki values = 1.3-20 nM and 20-142 nM respectively). Increases autophagy, both alone and in combination with VEGF inhibitors or Temozolomide (Cat. No. 2706), to reduce the progression of glioma and slow the proliferation of other tumors. Reprograms tumor-associated macrophages from immunosuppressive to immunostimulatory via histamine receptor inhibition.
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Spezifikation

Chemischer Name oder Material 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
CAS 113-52-0
Menge 50 mg
Ziel Autophagy-related Compounds
Summenformel C19H24N2.HCl
Titolo del prodotto
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