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IL-21 Monoclonal Antibody (mhalx21), eFluor™ 660, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 50-7213-82

274.01 CHF gültig bis 2024-03-29
Benutzen Sie den Promotions-Code "21615" um Ihren Promotions-Preis zu erhalten.



Additional Details : Gewicht : 0.25000kg

Artikelnummer. 15371950

  • 411.00 CHF / 100 Mikrogramm
Verfügbar ab: 07-05-2024
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Beschreibung

Beschreibung

IL-21 is a 17kDa immunomodulatory cytokine produced mainly by NKT, T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. This cytokine plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling innaive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. High levels of IL-21 are present in chemically-induced colitis models. IL-21-deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules.

IL-21 Monoclonal antibody specifically detects IL-21 in Mouse samples. It is validated for Flow Cytometry.
Spezifikation

Spezifikation

IL-21
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9ES17
IL21
Affinity chromatography
RUO
60505
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
mhalx21
eFluor 660
IL21
CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11
Rat
100 μg
Primary
Mouse
Antibody
IgG2a κ
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.