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IGF1R alpha Monoclonal Antibody (1H7), Invitrogen™
Mouse Monoclonal Antibody
Marke: Invitrogen MA181548
Additional Details : Gewicht : 0.01000kg
Beschreibung
This product requires protein digestion pre-treatment of paraffin sections using trypsin or pronase. A suggested positive control for immunohistochemical applications is pancreas or placenta. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL. Mouse anti Human CD221 antibody, clone 1H7 recognizes human CD221, a approximately 155 kDa receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor).
IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survial of malignant cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.Spezifikation
IGF1R alpha | |
Monoclonal | |
1 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
P08069 | |
Igf1r | |
Purified human placental IGF-I receptor | |
200 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
1H7 | |
Unconjugated | |
Igf1r | |
A330103N21Rik; CD221; D930020L01; hyft; IGF-1 receptor; Igf1r; IGF-1R; IGF-I receptor; IGFIR; IGFIRC; IGFR; Igfr1; insulin like growth factor 1 receptor; insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; insulin-like growth factor 1 receptor beta subunit; insulin-like growth factor I receptor; insulin-like growth factor receptor 1; insulin-like growth factor-I receptor; insulin-like growth factor-I receptor precursor; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2 | |
Mouse | |
Protein G | |
RUO | |
3480 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |