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Invitrogen™ IFNAR1 Monoclonal Antibody (85228), PE
Mouse Monoclonal Antibody
Marke: Invitrogen™ MA523630
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Beschreibung
In direct ELISAs, does not cross-react with recombinant human (rh) IFN- gamma R1, rhIFN-gamma R2, recombinant mouse IFN-alpha / beta R2, rhIL-10 R beta, rhIL-10 R alpha, or rhIL-20 R beta.
Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
Spezifikation
| IFNAR1 | |
| Monoclonal | |
| PE | |
| Ifnar1 | |
| alpha-type antiviral protein; AVP; beta-type antiviral protein; CD118; CRF2-1; cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; H3K1; Ifar; IFN R1; IFNalpha/beta R1; IFN-alpha/beta receptor 1; IFN-alpha/betaR; IFNalpha/betaR1; IFN-alpha/betaR1; IFN-alpha/betaRalpha; IFNalpha/beta-Ralpha; IFN-alpha-REC; IFNAR; Ifnar1; IFNBR; IFNR1; IFN-R-1; Ifrc; INF-a receptor; Infar; interferon (alpha and beta) receptor 1; interferon (alpha, beta and omega) receptor 1; interferon alpha and beta receptor subunit 1; interferon alpha/beta receptor 1; interferon receptor 1; interferon-alpha/beta receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; type I interferon receptor 1 | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 3454 | |
| 4°C, store in dark, DO NOT FREEZE! | |
| Liquid |
| Flow Cytometry | |
| 85228 | |
| Buffered saline solution with ≤ 0.5 BSA and 0.09% sodium azide | |
| P17181 | |
| Ifnar1 | |
| Sf 21-derived recombinant human IFN-alpha/beta R1 Lys28-Lys436. | |
| 100 Tests | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
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