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ACROBiosystems Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag

Marke:  ACROBiosystems TR1-H5254-100UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15817857

  • 299.38 CHF / 100 Mikrogramm


Verfügbar ab
04-06-2021
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Beschreibung

Beschreibung

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.0 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_003835
HEK293
Human
49.0 kDa
100 µg
Ala 24 - Asn 239
TNFRSF10A,TRAIL-R1,CD261,APO2,DR4
Unconjugated
50 mM Tris, 100 mM Glycine, pH7.5
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human TRAIL R1, Fc Tag (TR1-H5254) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Asn 239 (Accession # NP_003835).
-20°C
TRAIL R1
Fc Tag
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Sicherheitsdatenblatt (SDS)
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