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ACROBiosystems Human TIMP-2 Protein, His Tag
Marke: ACROBiosystems TI2-H5223-50UG
Additional Details : Gewicht : 0.00001kg
Beschreibung
TIMP metallopeptidase inhibitor 2 is also known as TIMP2, which belongs to the protease inhibitor I35 (TIMP) family. This family protein are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The TIMP family encompasses four members ( TIMP1, TIMP2, TIMP3, TIMP4 ), and they inhibit most MMPs by forming non-covalent binary complex. In addition to an inhibitory role against metalloproteinases, TIMP2 has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, TIMP-2 may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.6 kDa. The protein migrates as 23-26 kDa under reducing (R) condition (SDS-PAGE).Spezifikation
NP_003246.1 | |
50 μg | |
Cys 27 - Pro 220 | |
CSC-21 K,TIMP2 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |
22.6 kDa | |
Human TIMP-2, His Tag (TI2-H5223) is expressed from human 293 cells (HEK293). It contains AA Cys 27 - Pro 220 (Accession # NP_003246.1). | |
-20°C | |
TIMP-2 | |
Human | |
50 mM Tris, 150 mM NaCl, pH7.5 | |
HEK293 | |
Other Recombinant Proteins |