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ACROBiosystems Human TIM-3 / HAVCR2 Protein, His Tag
390.91 CHF - 2912.92 CHF
Spezifikation
Zugriffsnummer | NP_116171 |
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Molekulargewicht | 21.8 kDa |
Quelle | Human TIM-3, His Tag (TM3-H5229) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 200 (Accession # Q8TDQ0-1). |
Immunogen | Ser 22 - Arg 200 |
Lagerungsbedingungen | -20°C |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15837797
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ACROBiosystems
TM3-H5229-1MG |
1 mg |
2912.92 CHF
1 Milligramm |
Verfügbar ab: 10-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15827797
|
ACROBiosystems
TM3-H5229-100UG |
100 μg |
390.91 CHF
100 Mikrogramm |
Verfügbar ab: 10-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.8 kDa. The protein migrates as 44-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_116171 | |
Human TIM-3, His Tag (TM3-H5229) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 200 (Accession # Q8TDQ0-1). | |
-20°C | |
TIM-3 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Immune Checkpoint Proteins |
21.8 kDa | |
Ser 22 - Arg 200 | |
HAVCR2,TIM3,TIMD3,FLJ14428,KIM3 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |