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Gibco™ Human TGF-beta 3 Recombinant Protein, PeproTech®

Artikelnummer. 17840653
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Product Code. Menge unitSize
17840653 100 μg 100 Mikrogramm
17880643 10 μg 10 Mikrogramm
17860653 1 mg 1 Milligramm
17879882 250 μg 250 Mikrogramm
17831023 2 μg 2 Mikrogramm
17890263 500 μg 500 Mikrogramm
17890443 50 μg 50 Mikrogramm
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Product Code. 17840653 missing translation for 'mfr' Gibco™ missing translation for 'supplierNo' 10036E100UG

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Description

Recombinant Protein

Recombinant Human TGF-beta3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
TRUSTED_SUSTAINABILITY

Specifications

Zugriffsnummer P10600
Zur Verwendung mit (Anwendung) ELISA, Functional Assay, Western Blot
Zusammensetzung protein with no preservative
Gen-ID (Entrez) 7043
Molekulargewicht 25 kDa
Name Human TGF-beta 3
Menge 100 μg
Quelle E. coli
Kennzeichnung RUO
Endotoxin-Konzentration <1 EU/ μg
Gen-Alias ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
Gebräuchliche Bezeichnung TGF beta-3
Gensymbol TGFB3
Biologische Aktivität The ED50 was determined by TGF-beta3's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10^7 units/mg
Konjugat Unconjugated
Rekombinant Recombinant
Sequenz ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
Inhalt und Lagerung -20°C
Expressionssystem E. coli
Form Lyophilized
Reinheits- oder Qualitätsgrad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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