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ACROBiosystems Human SIRP alpha / CD172a Protein, Fc Tag
MALS verified
327.86 CHF - 2774.20 CHF
Spezifikation
Zugriffsnummer | NP_001035111 |
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Molekulargewicht | 63.9 kDa |
Quelle | Human SIRP alpha, Fc Tag (SIA-H5251) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - Arg 370 (Accession # NP_001035111). |
Immunogen | Glu 31 - Arg 370 |
Lagerungsbedingungen | -20°C |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15827697
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ACROBiosystems
SIA-H5251-1MG |
1 mg |
2774.20 CHF
1 Milligramm |
Verfügbar ab: 30-04-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15817697
|
ACROBiosystems
SIA-H5251-100UG |
100 μg |
327.86 CHF
100 Mikrogramm |
Verfügbar ab: 30-04-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.9 kDa. The protein migrates as 70-105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_001035111 | |
Human SIRP alpha, Fc Tag (SIA-H5251) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - Arg 370 (Accession # NP_001035111). | |
-20°C | |
SIRP alpha | |
Human | |
50 mM Tris, 100 mM Glycine, pH7.5 | |
HEK293 | |
Immune Checkpoint Proteins |
63.9 kDa | |
Glu 31 - Arg 370 | |
SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1 | |
Unconjugated | |
Fc Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |