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ACROBiosystems Human ROR1 Protein, Fc Tag

Marke:  ACROBiosystems RO1-H5250-1MG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15817597

  • 1128.43 CHF / 1 Milligramm


Verfügbar ab
28-05-2021
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Beschreibung

Beschreibung

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 68.6 kDa. The protein migrates as 79-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_005003.2
HEK293
Human
68.6 kDa
1 mg
Gln 30 - Glu 403
ROR1,NTRKR1
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>90% as determined by SDS-PAGE
Human ROR1, Fc Tag (RO1-H5250) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Glu 403 (Accession # Q01973-1).
-20°C
ROR1
Fc Tag
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