missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Human PD-1 / PDCD1 Protein, Llama IgG2b Fc Tag, low endotoxin

low endotoxin

437.70 CHF - 3214.00 CHF

Spezifikation

Zugriffsnummer NP 005009.2
Molekulargewicht 43.8 kDa
Quelle Human PD-1, Llama IgG2b Fc Tag, low endotoxin (PD1-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gln 167 (Accession # Q15116-1).
Immunogen Leu 25 - Gln 167
Lagerungsbedingungen -20°C
Mehr Spezifikationen ansehen

Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15817467
Unterlagen ansehen Aktionsdetails
ACROBiosystems
PD1-H5259-100UG
100 μg
437.70 CHF
100 Mikrogramm
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 11-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
15827467
Unterlagen ansehen Aktionsdetails
ACROBiosystems
PD1-H5259-1MG
1 mg
3214.00 CHF
1 Milligramm
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 11-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.

This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 43.8 kDa. The protein migrates as 55-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP 005009.2
Human PD-1, Llama IgG2b Fc Tag, low endotoxin (PD1-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gln 167 (Accession # Q15116-1).
-20°C
PD-1
Human
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Immune Checkpoint Proteins
43.8 kDa
Leu 25 - Gln 167
PDCD1,PD1,CD279,SLEB2
Unconjugated
Llama IgG Fc Tag
Less than 0.01 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications