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ACROBiosystems Human PCSK9 (R194A) Protein, His Tag

Marke:  ACROBiosystems PCA-H5226-50UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15817447

  • 299.38 CHF / 50 Mikrogramm


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28-05-2021
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Beschreibung

Beschreibung

Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

This protein is fused with a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent interactions and with a calcu
Spezifikation

Spezifikation

AAI166619.1
HEK293
Human
13.8 kDa and 58.0 kDa
50 µg
Gln 31 - Gln 692
PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human PCSK9 (R194A), His Tag (PCA-H5226) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gln 692 (Accession # AAI166619.1).
-20°C
PCSK9
His Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation