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ACROBiosystems Human PCSK9 (R194A) Protein, His Tag
Marke: ACROBiosystems PCA-H5226-50UG
Additional Details : Gewicht : 0.00001kg
Beschreibung
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
This protein is fused with a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent interactions and with a calcuSpezifikation
| AAI166619.1 | |
| 50 μg | |
| Gln 31 - Gln 692 | |
| PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 13.8 kDa and 58.0 kDa | |
| Human PCSK9 (R194A), His Tag (PCA-H5226) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gln 692 (Accession # AAI166619.1). | |
| -20°C | |
| PCSK9 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers and CD Antigens |