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ACROBiosystems Human Osteoprotegerin / TNFRSF11B Protein, His Tag

Marke:  ACROBiosystems TNB-H5220-100UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15827847

  • 207.26 CHF / 100 Mikrogramm


Verfügbar ab
04-06-2021
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Beschreibung

Beschreibung

Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 44.4 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_002537
HEK293
Human
44.4 kDa
100 µg
Glu 22 - Leu 401
TNFRSF11B,OCIF,OPG,Osteoprotegerin
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Other Recombinant Proteins
Powder
>95% as determined by SDS-PAGE
Human Osteoprotegerin, His Tag (TNB-H5220) is expressed from human 293 cells (HEK293). It contains AA Glu 22 - Leu 401 (Accession # NP_002537).
-20°C
Osteoprotegerin
His Tag
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Sicherheitsdatenblatt (SDS)
Dokumentation