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ACROBiosystems Human Neprilysin / MME / CD10 Protein, Tag Free

Marke:  ACROBiosystems MME-H521B-50UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15817317

  • auf Anfrage / 50 Mikrogramm

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Beschreibung

Beschreibung

Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).

This protein carries no "e;tag"e;. The protein has a calculated MW of 80.0 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_000893.2
HEK293
Human
80.0 kDa
50 µg
Tyr 52 - Trp 750
MME,CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP,SFE,Neprilysin
Unconjugated
20 mM Tris, 100 mM NaCl, pH8.0
Less than 1.0 EU / µg by the LAL method.
Enzymes
Powder
>95% as determined by SDS-PAGE
Human Neprilysin, Tag Free (MME-H521b) is expressed from human 293 cells (HEK293). It contains AA Tyr 52 - Trp 750 (Accession # NP_000893.2).
-20°C
Neprilysin
Tag Free
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation