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ACROBiosystems Human Neprilysin / MME / CD10 Protein, Fc Tag

Marke:  ACROBiosystems MME-H526A-1MG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15827317

  • 1934.46 CHF / 1 Milligramm


Verfügbar ab
04-06-2021
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Beschreibung

Beschreibung

Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 106.8 kDa. The protein migrates as 106-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_000893.2
HEK293
Human
106.8 kDa
1 mg
Tyr 52 - Trp 750
MME,CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP,SFE,Neprilysin
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human Neprilysin, Fc Tag (MME-H526a) is expressed from human 293 cells (HEK293). It contains AA Tyr 52 - Trp 750 (Accession # NP_000893.2).
-20°C
Neprilysin
Fc Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation