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ACROBiosystems Human M-CSF R / CSF1R / CD115 Protein, His Tag

HPLC-verified

Marke:  ACROBiosystems CSR-H5228-200UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15826497

  • 264.84 CHF / 200 Mikrogramm


Verfügbar ab
27-05-2021
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Beschreibung

Beschreibung

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeIII subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.3 kDa. The protein migrates as 80-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_005202.2
HEK293
Human
55.3 kDa
200 µg
Ile 20 - Glu 512
CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>96% as determined by SDS-PAGE
Human M-CSF R, His Tag (CSR-H5228) is expressed from human 293 cells (HEK293). It contains AA Ile 20 - Glu 512 (Accession # NP_005202.2).
-20°C
M-CSF R
His Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation