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ACROBiosystems Human LILRB4 / CD85k / ILT3 Protein, Fc Tag
SPR verified
Marke: ACROBiosystems LI4-H5259-50UG
Additional Details : Gewicht : 0.00001kg
Beschreibung
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.9 kDa. The protein migrates as 57-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| AAH26309 | |
| 50 µg | |
| Gln 22 - Glu 259 | |
| LILRB4,ILT3,LIR5,CD85K,HM18 | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / µg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 52.9 kDa | |
| Human LILRB4, Fc Tag (SPR verified) (LI4-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Glu 259 (Accession # AAH26309). | |
| -20°C | |
| LILRB4 | |
| Human | |
| 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| Immune Checkpoint Proteins |