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Gibco™ Human Klotho Recombinant Protein, PeproTech®
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Menge:
100 μg
2 x 500 μg
20 μg
250 μg
5 μg
500 μg
Packungsgröße:
1 Milligramm
100 Mikrogramm
2 Stück
20 Mikrogramm
250 Mikrogramm
5 Mikrogramm
500 Mikrogramm
Beschreibung
100-53-1MG will be provided as 2 x 500 μg (100-53-500UG). Recombinant Human Klotho is a glycoprotein of 516 amino acid residues that migrates at an apparent molecular weight of 65-70 kDa by SDS-PAGE analysis under reducing conditions. Recombinant Human Klotho has a calculated molecular weight of 58.6 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
Spezifikation
Spezifikation
| Zugriffsnummer | Q9UEF7 |
| Zur Verwendung mit (Anwendung) | Control, Western Blot Control, Bioactivity |
| Zusammensetzung | Protein with no preservative |
| Gen-ID (Entrez) | 9365 |
| Molekulargewicht | 58.6 kDa |
| Name | Human Klotho |
| Reinigungsverfahren | Purified |
| Menge | 100 μg |
| Quelle | CHO cells |
| Lagerungsbedingungen | -20°C |
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