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ACROBiosystems Human Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free
Marke: ACROBiosystems IT5-H52W5-100UG
Additional Details : Gewicht : 0.00001kg
Beschreibung
Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
Human ITGAV&ITGB5 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB5, has a calculated MW of 112.9 kDa (ITGAV) and 81.9 kDa (ITGB5). Subunit ITGAV is fused with polyhistidine tag at the C-terminus and followed by a acidicSpezifikation
| NP_002201.1 (ITGAV) and NP_002204.2 (ITGB5) | |
| 100 μg | |
| Phe 31 - Val 992 (ITGAV) and Gly 24 - Asn 719 (ITGB5) | |
| Integrin alpha V beta 5,ITGAVandITGB5 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 112.9 kDa (ITGAV) and 81.9 kDa (ITGB5) | |
| Human ITGAV&ITGB5; Heterodimer Protein, His Tag&Tag; Free (IT5-H52W5) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) and Gly 24 - Asn 719 (ITGB5) (Accession # NP_002201.1 (ITGAV) and NP_002204.2 (ITGB5)). | |
| -20°C | |
| Integrin alpha V beta 5 | |
| Human | |
| 50 mM Tris, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |