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ACROBiosystems Human IL-2 R gamma / CD132 Protein, Fc Tag

Marke:  ACROBiosystems ILG-H5256-100UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15817107

  • 287.87 CHF / 100 Mikrogramm


Verfügbar ab
04-06-2021
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Beschreibung

Beschreibung

IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 53.5 kDa. The protein migrates as 75-96 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

AAH14972
HEK293
Human
53.5 kDa
100 µg
Leu 23 - Asn 254
IL2RG,CD132,CIDX,IMD4,P64,SCIDX,SCIDX1,gammaC
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human IL-2 R gamma, Fc Tag (ILG-H5256) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Asn 254 (Accession # AAH14972).
-20°C
IL-2 R gamma
Fc Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation