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ACROBiosystems Human Growth Hormone R (GHR) Protein, Fc Tag

Marke:  ACROBiosystems GHR-H5257-50UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15826837

  • 287.87 CHF / 50 Mikrogramm


Verfügbar ab
28-05-2021
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Beschreibung

Beschreibung

Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 54.3 kDa. As a result of glycosylation, the protein migrates as 66-85 kDa under reducing (R) condition, and 135-160 kDa under non-reducing (NR) condition (SDS-P
Spezifikation

Spezifikation

P10912
HEK293
Human
54.3 kDa
50 µg
Ala 27 - Tyr 264
GHR,GHBP,GH receptor
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human GHR, Fc Tag (GHR-H5257) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Tyr 264 (Accession # P10912).
-20°C
Growth Hormone R
Fc Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation