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Gibco™ Human GDNF Recombinant Protein

Codice prodotto. 10679963 Sfoglia Tutto Gibco Prodotti
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Quantità:
1 mg
10 μg
100 μg
5 μg
Dimensione della confezione:
Pezzo
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Codice prodotto. Quantità Dimensione della confezione
10679963 10 μg Pezzo
10641504 100 μg Pezzo
10737683 1 mg Pezzo
10110633 5 μg Pezzo
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Codice prodotto. 10679963 Fornitore Gibco™ N. del fornitore PHC7045
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Recombinant Protein

Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute lyophilized human GDNF in sterile, distilled water to 0.1-0.5 mg/mL. These stock solutions should be apportioned into working aliquots and stored at ≤-20°C. Further dilution should be made in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Lyophilized human GDNF should be stored at 2°C to 8°C, preferably desiccated. Store reconstituted human GDNF at ≤-20°C (not in a frost-free freezer). Keep freeze-thaw cycles to a minimum.

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
TRUSTED_SUSTAINABILITY

Specifica

Numero di accesso P39905
Da utilizzare con (applicazione) Bioactivity
Formulazione Protein with no preservative
ID gene (immissione) 2668
Peso molecolare 30.1 kDa
Nome Human GDNF
Metodo di purificazione Purified
Quantità 10 μg
Requisiti di stoccaggio 4°C
Status giuridico RUO
Concentrazione di endotossine <0.1 ng/μg
Alias gene AI385739; Astrocyte-derived trophic factor; ATF; ATF1; ATF2; Gdnf; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; glial cell line-derived neurotrophic factor; gndf; HFB1-GDNF; hGDNF; H-GDNF; HSCR3; mGDNF; neurotrophic factor
Nome comune GDNF
Simbolo del gene GDNF
Attività biologica ED50 ≤ 10 n/mL; determined by the dose-dependent neurite outgrowth of PC-12 cells in the presence of soluble GFR-alpha.
Product Type Protein
Coniugato Unconjugated
Specie Human
Recombinant Recombinant
Sequenza SPDKQMAVLP RRERNRQAAA ANPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCDAAETTYD KILKNLSRNR RLVSDKVGQA CCRPIAFDDD LSFLDDNLVY HILRKHSAKR CGCI
Content And Storage 4°C
Classificazione Carrier-Free
Attività ED50 ≤ 10 n/mL; determined by the dose-dependent neurite outgrowth of PC-12 cells in the presence of soluble GFR-alpha.
Livello di endotossine <0.1 ng/μg
Shipping Condition Approved for shipment on Wet or Dry Ice
Sistema di espressione E. coli
Famiglia di proteine Growth Factors & Receptors
Protein Form Recombinant, Ligand
Forma Lyophilized
Sottotipo di proteina Neurotrophic Factors
Research Category Neurobiology, Stem Cell Research, Differentiation
Linea di prodotti Gibco
Purity or Quality Grade >98% by SDS-PAGE
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