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Gibco™ Human FGF-basic (FGF-2/bFGF) (aa 10-155) Recombinant Protein

Codice prodotto. 10202733 Sfoglia Tutto Gibco Prodotti
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Quantità:
1 mg
10 μg
100 μg
50 μg
Dimensione della confezione:
100 UG
50 UG
Pezzo
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Codice prodotto. Quantità Dimensione della confezione
10202733 100 μg 100 UG
10612074 1 mg Pezzo
10622074 10 μg Pezzo
10222253 50 μg 50 UG
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Codice prodotto. 10202733 Fornitore Gibco™ N. del fornitore PHG0021
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Descrizione

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water to 0.1-0.5 mg/mL. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C (not in a frost-free freezer). Avoid repeated freeze-thaw cycles.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
TRUSTED_SUSTAINABILITY

Specifica

Numero di accesso P09038
Da utilizzare con (applicazione) Bioactivity
Formulazione Protein with no preservative
ID gene (immissione) 2247
Peso molecolare 17 kDa
Nome Human FGF-basic (FGF-2/bFGF) (aa 10-155)
Metodo di purificazione Purified
Quantità 100 μg
Requisiti di stoccaggio 4°C
Status giuridico RUO
Concentrazione di endotossine <0.1 ng/μg
Alias gene Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); Fibroblast growth factor basic; HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
Nome comune FGF2
Simbolo del gene FGF2
Attività biologica ED50 ≤ 1.0 ng/mL; determined by the dose-dependent proliferation of BALB/3T3 cells.
Product Type Protein
Coniugato Unconjugated
Specie Human
Recombinant Recombinant
Sequenza Human FGF-basic, amino acids 10-155
Content And Storage 4°C
Attività ED50 ≤ 1.0 ng/mL; determined by the dose-dependent proliferation of BALB/3T3 cells.
Livello di endotossine <0.1 ng/μg
Shipping Condition Wet Ice
Sistema di espressione E. coli
Famiglia di proteine Growth Factors & Receptors
Protein Form Recombinant, Ligand, Truncated
Forma Lyophilized
Sottotipo di proteina FGFs (Fibroblast Growth Factors)
Research Category Neurobiology, Oncology, Stem Cell Research, Microbiology, Differentiation, Angiogenesis
Linea di prodotti Gibco
Purity or Quality Grade >95% by SDS-PAGE
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