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Fc Receptor Binding Inhibitor Polyclonal Antibody, eBioscience™, Invitrogen™

Polyclonal Antibody

116.00 CHF - 210.00 CHF

Spezifikation

Antigen Fc Receptor Binding Inhibitor
Konzentration 1 mg/mL
Anwendungen Flow Cytometry
Klassifikation Polyclonal
Konjugat Unconjugated
Mehr Spezifikationen ansehen

Benachrichtigungen:

Contains Azide


Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15218157
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Affymetrix eBioscience
14-9161-71
25 Tests
116.00 CHF
25 Tests
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15228157
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
14-9161-73
100 Tests
210.00 CHF
100 Tests
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Lager vorrätig
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

Description: The human FcgammaR-binding inhibitor can be used to inhibit the non-specific Fc-gamma receptor (FcgammaR)-mediated binding of mouse monoclonal antibodies used for flow cytometric analysis of human tissue. Four different classes of Fcgamma receptors have been identified: FcgammaRI (CD64), FcgammaRII (CD32), and FcgammaRIII (CD16), and they are expressed at varying levels in multiple cell lineages including high expression in myeloid, granulocyte and B cells. The biological function of the FcgammaR, including initiation of endocytosis, phagocytosis and antigen presentation, is elicited upon binding of host-immunoglobulin. The extent to which mouse monoclonal antibodies will bind to human FcgammaR varies depending on the isotype of the monoclonal antibody. Furthermore, different monoclonal antibodies of the same isotype will display different binding to human FcgammaRs. Applications Reported: Purified Fc Receptor Binding Inhibitor has been reported for use in flow cytometric analysis. To inhibit the non-specific binding of mouse monoclonal antibodies add the human Fc Receptor Binding Inhibitor to samples and incubate on ice for 20 minutes. Without washing proceed to stain with primary antibody. Applications Tested: Purified human Fc gammaR-binding inhibitor has been pre-titrated and tested by inhibiting binding of fluorochrome-conjugated isotype controls to U937 cells. This can be used at 20 μL per test.

Four different classes of Fcy receptors have been identified: FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD16), and they are expressed at varying levels in multiple cell lineages including high expression in myeloid, granulocyte and B cells. The biological function of the FcyR, including initiation of endocytosis, phagocytosis and antigen presentation, is elicited upon binding of host-immunoglobulin. The extent to which mouse monoclonal antibodies will bind to human FcyR varies depending on the isotype of the monoclonal antibody. Furthermore, different monoclonal antibodies of the same isotype will display different binding to human FcyRs.
Spezifikation

Spezifikation

Fc Receptor Binding Inhibitor
Flow Cytometry
Unconjugated
Human
Human
Fc blocking; FcR BI; FcR Inhibitor
Affinity chromatography
Antibody
1 mg/mL
Polyclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
Primary
4° C
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Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications

For Research Use Only