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ACROBiosystems Human Fc gamma RIIB / CD32b Protein, His Tag

SPR & BLI verified

Marke:  ACROBiosystems CDB-H5228-1MG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15826367

  • auf Anfrage / 1 Milligramm

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Beschreibung

Beschreibung

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 25-33 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Spezifikation

Spezifikation

NP_001002273.1
HEK293
Human
20.4 kDa
1 mg
Ala 46 - Pro 217
FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
MABSol™ Fc Receptors
Powder
>95% as determined by SDS-PAGE
Human CD32b, His Tag (SPR and BLI verified) (CDB-H5228) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 217 (Accession # P31994).
-20°C
Fc gamma RIIB / CD32b
His Tag
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Sicherheitsdatenblatt (SDS)
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