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ACROBiosystems Human CD47 Protein, Mouse IgG2a Fc Tag, low endotoxin
low endotoxin
Marke: ACROBiosystems CD7-H52A5-1MG
Additional Details : Gewicht : 0.00001kg
Beschreibung
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.8 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_942088 | |
| 1 mg | |
| Gln 19 - Pro 139 | |
| CD47,MER6,IAP,OA3 | |
| Unconjugated | |
| Mouse IgG Fc Tag | |
| Less than 0.1 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 40.8 kDa | |
| Human CD47, Mouse IgG2a Fc Tag, low endotoxin (CD7-H52A5) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Pro 139 (Accession # NP_942088). | |
| -20°C | |
| CD47 | |
| Human | |
| 50 mM Tris, 100 mM Glycine, pH7.5 | |
| HEK293 | |
| Immune Checkpoint Proteins |