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ACROBiosystems Human CD31 / PECAM-1 Protein, His Tag

Marke:  ACROBiosystems CD1-H5224-1MG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15826147

  • 1658.11 CHF / 1 Milligramm


Verfügbar ab
27-05-2021
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Beschreibung

Beschreibung

Cluster of Differentiation 31 (CD31) is also known as Platelet endothelial cell adhesion molecule (PECAM-1), is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, osteoclasts, neutrophils, certain tumors, and is the only known member of the CAM family on platelets. CD31 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. CD31 plays a key role in removing aged neutrophils from the body. CD31 mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin αvβ3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. In addition, it has been shown that CD31 expression is up-regulated by LPS stimulation, and might function as a feedback negative regulator of LPS inflammatory response in macrophages.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 66.4 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_000433.4
HEK293
Human
66.4 kDa
1 mg
Gln 28 - Lys 601
PECAM1,CD31,FLJ34100,FLJ58394
Unconjugated
50 mM Tris, 150 mM NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human CD31, His Tag (CD1-H5224) is expressed from human 293 cells (HEK293). It contains AA Gln 28 - Lys 601 (Accession # P16284-1).
-20°C
CD31
His Tag
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Sicherheitsdatenblatt (SDS)
Dokumentation