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ACROBiosystems Human CD3 epsilon Protein, Fc,His Tag

Marke:  ACROBiosystems CDE-H5256-1MG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15826397

  • 2153.24 CHF / 1 Milligramm


Verfügbar ab
04-06-2021
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Beschreibung

Beschreibung

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

This protein carries a human IgG1 Fc tag at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 39.2 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_000724.1
HEK293
Human
39.2 kDa
1 mg
Asp 23 - Asp 126
FLJ18683,T3E,TCRE,CD3E,CD3-epsilon
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human CD3 epsilon, Fc,His Tag (CDE-H5256) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126 (Accession # NP_000724.1).
-20°C
CD3 epsilon
His Tag and Fc Tag
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Sicherheitsdatenblatt (SDS)
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