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ACROBiosystems Human CD14 Protein, His Tag

Marke:  ACROBiosystems CD4-H5228-100UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15826187

  • 299.38 CHF / 100 Mikrogramm


Verfügbar ab
28-05-2021
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Beschreibung

Beschreibung

Cluster of differentiation 14 (CD14), is a cell surface glycoprotein, and is a is a component of the innate immune system. CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa). CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells. Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns. CD14+ cells are monocytes that can differentiate into a host of different cells. CD14 has been shown to interact with Lipopolysaccharide-binding protein.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 35.9 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

AAH10507
HEK293
Human
35.9 kDa
100 µg
Thr 20 - Met 344
CD14
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>98% as determined by SDS-PAGE
Human CD14, His Tag (CD4-H5228) is expressed from human 293 cells (HEK293). It contains AA Thr 20 - Met 344 (Accession # AAH10507).
-20°C
CD14
His Tag
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Sicherheitsdatenblatt (SDS)
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