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ACROBiosystems Human B7-2 / CD86 Protein, Fc Tag
428.74 CHF - 1828.46 CHF
Spezifikation
Zugriffsnummer | AAH40261 |
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Molekulargewicht | 51.5 kDa |
Quelle | Human B7-2, Fc Tag (CD6-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Pro 247 (Accession # AAH40261). |
Immunogen | Leu 26 - Pro 247 |
Lagerungsbedingungen | -20°C |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15826237
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ACROBiosystems
CD6-H5257-1MG |
1 mg |
1828.46 CHF
1 Milligramm |
Verfügbar ab: 03-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15836237
|
ACROBiosystems
CD6-H5257-200UG |
200 μg |
428.74 CHF
200 Mikrogramm |
Verfügbar ab: 03-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.5 kDa. As a result of glycosylation, the protein migrates as 66-86 kDa under reducing (R) condition, and 120-140 kDa under non-reducing (NR) condition (SDS-PSpezifikation
AAH40261 | |
Human B7-2, Fc Tag (CD6-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Pro 247 (Accession # AAH40261). | |
-20°C | |
B7-2 | |
Human | |
Tris with Glycine, Arginine and NaCl, pH7.5 | |
HEK293 | |
Immune Checkpoint Proteins |
51.5 kDa | |
Leu 26 - Pro 247 | |
CD86,B7-2,B70,CD28LG2,LAB72,MGC34413 | |
Unconjugated | |
Fc Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |