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ACROBiosystems Human Annexin A5 Protein, His Tag
Marke: ACROBiosystems AN5-H5123-100UG
Additional Details : Gewicht : 0.00001kg
Beschreibung
Annexin A5 is a phospholipid binding protein, which binds with high affinity and selectivity to PS in the presence of calcium. PS is predominantly located in membrane leaflets, which face the cytosol. However, recent findings show that each cell type has the molecular machinery to expose PS at its cell surface. This machinery is activated during the execution of apoptosis. Once PS is exposed at the cell surface it exhibits procoagulant and proinflammatory activities. Annexin A5 will bind to the PS-exposing apoptotic cell and can inhibit the procoagulant and proinflammatory activities of the dying cell. Annexin A5 has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Annexin A5 is associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc).
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.8 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE).Spezifikation
| AAH01429 | |
| 100 μg | |
| Met 1 - Asp 320 | |
| ANXA5,ANX5,ENX2,PP4,Annexin V,Annexin A5 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >98% as determined by SDS-PAGE |
| 36.8 kDa | |
| Human Annexin A5, His Tag (AN5-H5123) is expressed from E.coli cells. It contains AA Met 1 - Asp 320 (Accession # P08758-1). | |
| -20°C | |
| Annexin A5 | |
| Human | |
| PBS, pH7.4 | |
| E.coli | |
| Other Recombinant Proteins |