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HBP1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 11746-1-AP-20UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16839033

  • 131.19 CHF / 20 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

This is a rabbit polyclonal antibody raised against the C-terminus of human HBP1.

The HMG-box protein-1 (HBP1) is a member of the HMG family of transcription factors, which are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, that mediates DNA binding. HBP1 binds to the tumor suppressor proteins Rb and p130 and initiates cell cycle arrest. Terminal cell differentiation requires this initial cell cycle arrest followed by the coordinated expression of genes defined as tissue-specific markers. Along with initiating the commitment to cell differentiation, the continued activity of HBP1 abrogates the expression of tissue-specific genes by associating with the MyoD proteins. In muscle cell differentiation, the MyoD family of transcription factors, which include Myf5, MyoD and myogenein, induce the expression of these cell-type specific proteins and contribute to the development of cell phenotypes. The progression of terminal differentiation is, therefore, dependent on both a decrease in HBP1 activity and the corresponding activation of MyoD-induced gene transcription.
Spezifikation

Spezifikation

HBP1
Polyclonal
Unconjugated
HBP1
HBP1, HMG box containing protein 1, HMG box transcription factor 1
Rabbit
Antigen Affinity Chromatography
RUO
26959, 73389
Antibody
IgG
Western Blot, Immunoprecipitation, Immunocytochemistry, Immunofluorescence
0.09 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O60381, Q8R316
Hbp1
HBP1 Fusion Protein Ag2342
20 μL
Primary
Human, Mouse
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote