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ACROBiosystems Hamster PCSK9 Protein, His Tag

325.15 CHF - 2751.28 CHF

Spezifikation

Molekulargewicht 13.9 kDa and 59.0 kDa
Quelle Hamster PCSK9, His Tag (PC9-H52E4) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 691 (Accession # G3GTK5).
Immunogen Gln 30 - Ser 691
Lagerungsbedingungen -20°C
Gen-Alias PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15817437
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ACROBiosystems
PC9-H52E4-1MG
1 mg
2751.28 CHF
1 Milligramm
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Verfügbar ab: 11-04-2024
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15827437
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ACROBiosystems
PC9-H52E4-50UG
50 μg
325.15 CHF
50 Mikrogramm
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Verfügbar ab: 11-04-2024
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Beschreibung

Beschreibung

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

This protein carries a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent interactions and with a calculated
Spezifikation

Spezifikation

13.9 kDa and 59.0 kDa
Gln 30 - Ser 691
PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9
Unconjugated
PBS, pH7.4
HEK293
Bio-Markers and CD Antigens
Hamster PCSK9, His Tag (PC9-H52E4) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 691 (Accession # G3GTK5).
-20°C
PCSK9
His Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
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