GSPT1 Polyclonal Antibody, Invitrogen™

Beschreibung

Recommended positive controls: 293T, A431, HeLa, HepG2. Predicted reactivity: Mouse (91%), Rat (93%), Chicken (81%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

eRF3a (eukaryotic peptide chain release factor subunit 3a), also known as GSPT1 (G1 to S phase transition 1), is a 499 amino acid protein that belongs to the GTP-binding elongation factor family and is involved in the regulation of cell growth, specifically via control of translation termination. Human eRF3a shares 94% sequence identity with its mouse counterpart, suggesting a conserved function between species. The gene encoding eRF3a maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth.