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AcroBiosystems GMP Human IL-6 Protein
Beschreibung
Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.
Spezifikation
Spezifikation
| Zugriffsnummer | Uniprot |
| Charakterisierung | IL-6 Structure This protein carries no tag. The protein has a calculated MW of 20.8 kDa. The protein migrates as 23-29 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Format | Powder-GMP |
| Zusammensetzung | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with protectants. Contact us for customized product form or formulation. |
| Qualitätskontrollen | <0.5 ng/μg of protein tested by ELISA.∣<0.02 ng/μg of protein tested by qPCR.∣Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.∣Sterility testing was performed using the membrane filtration method in compliance with USP &CM and Ph. Eur. 2.6.1.∣Negative |
| Menge | 10 mg |
| Quelle | GMP Human IL-6 Protein (GMP-L06H27) is expressed from human 293 cells (HEK293). It contains AA Val 30 - Met 212 (Accession # ). Predicted N-terminus: Val 30 Request for sequence |
| Biologische Aktivität | GMP Human IL-6 Protein (Cat. No. GMP-L06H27) stimulates proliferation of TF-1 human erythroleukemic cell line. The specific activity of GMP Human IL-6 Protein is >1.00x10^8 IU/mg, which is calibrated against human IL-6 WHO International Standard (NIBSC code: 21/308) (QC tested).∣The activity of GMP Human IL-6 Protein (Cat. No. GMP-L06H27) was higher than other competing products.∣GMP Human SCF Protein (Cat. No. GMP-SCFH25), Human Flt-3 Ligand Protein (Cat. No. GMP-FLLH28), GMP Human IL-3 Protein (Cat. No. GMP-L03H18) and GMP Human IL-6 Protein (Cat. No. GMP-L06H27) could support the rapid cell expansion and good cell viability of CD34+ hematopoietic stem cells.∣The Cell based assay shows that GMP Human IL-6 Protein (Cat. No. GMP-L06H27) is stable at 37 °C for 24 hours.∣The Cell based assay shows that GMP Human IL-6 Protein (Cat. No. GMP-L06H27) is stable after freezing and thawing 3 times.∣The Cell based assay shows that GMP Human IL-6 Protein (Cat. No. GMP-L06H27) is stable at 4°C for 6 months.∣The Cell based assay shows batch-to-batch consistency between Acro's GMP and PG IL-6. |
| Spezies | Human |
| Sterilität | Sterile |
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